| Popis: |
Twenty patients with increased bone resorption (osteoporosis, 6; Paget's disease, 2; multiple myeloma, 5; cancer, 7) received clodronate 300 mg by 1-hr infusion for 7 days. There was a significant decrease in serum calcium, alkaline phosphatase, and urinary hydroxyproline in all patients, and a prompt improvement of bone pain occurred concomitantly. No significant changes in circulating beta-endorphin concentration during the week of therapy were observed. Changes in the beta-endorphin concentrations were evaluated by a 2-hr period of blood sampling during and after the drug infusion and by daily determinations. Data suggest that the clodronate-induced analgesic effect is probably due to a peripheral action on osteoclasts in absence of any central effect. |
