| Popis: |
Although the pathogenesis of Autoimmune Hepatitis (AIH) is unknown, the susceptibility is determined in part by genes linked to the region of HLA class II. The study included 47 unrelated individuals with the diagnostic of type 1 AIH. A control group (n = 81) of healthy individuals was included. The alleles were tested for HLA class II genotyping using polymerase chain reaction and sequence-specific primers technique (PCR-SSP). Among patients with AIH alleles occurring at higher frequencies were DRB1*04, DRB1*03, DRB1*01, DRB1*07 and DRB1*13. With reference to controls the following alleles were the most prevalent DRB1*07, DRB1*11, DRB1*08, DRB1*13 and DRB1*01. In comparison with the control group, AIH patients revealed a greater occurrence of the DRB1*03 and DRB1*04. These alleles can be considered as predisposing factors for the development of AIH. By contrast, DRB1*08 and DRB1*11 alleles were less frequent among patients and hence could be involved in disease resistance. |
