Evaluation of insertion characteristics of less invasive Si optoneural probe with embedded optical fiber
| Autor: | Tetsu Tanaka, Hisashi Kino, Takumi Morikawa, Takafumi Fukushima, Takuya Harashima |
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| Rok vydání: | 2017 |
| Předmět: |
Optical fiber
Materials science genetic structures Physics and Astronomy (miscellaneous) business.industry 0206 medical engineering General Engineering Less invasive General Physics and Astronomy Light irradiation 02 engineering and technology 020601 biomedical engineering eye diseases law.invention 03 medical and health sciences 0302 clinical medicine Optics law sense organs Irradiation business Electrical impedance 030217 neurology & neurosurgery Leakage (electronics) |
| Zdroj: | Japanese Journal of Applied Physics. 56:04CM08 |
| ISSN: | 1347-4065 0021-4922 |
| Popis: | A less invasive Si optoneural probe with an embedded optical fiber was proposed and successfully fabricated. The diameter of the optical fiber was completely controlled by hydrogen fluoride etching, and the thinned optical fiber can propagate light without any leakage. This optical fiber was embedded in a trench formed inside a probe shank, which causes less damage to tissues. In addition, it was confirmed that the optical fiber embedded in the probe shank successfully irradiated light to optically stimulate gene transfected neurons. The electrochemical impedance of the probe did not change despite the light irradiation. Furthermore, probe insertion characteristics were evaluated in detail and less invasive insertion was clearly indicated for the Si optoneural probe with the embedded optical fiber compared with conventional optical neural probes. This neural probe with the embedded optical fiber can be used as a simple and easy tool for optogenetics and brain science. |
| Databáze: | OpenAIRE |
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