Regioselective halogenation of pyridinium N-(benzoazynyl) aminides as a way to produce N-benzyl-α-aminobenzoazines

Autor:	Elena Gala, Julio Alvarez-Builla, M. Luisa Izquierdo
Rok vydání:	2018
Předmět:	Diazine 010405 organic chemistry Chemistry Organic Chemistry Halogenation Regioselectivity Alkylation 010402 general chemistry 01 natural sciences Biochemistry Medicinal chemistry 0104 chemical sciences chemistry.chemical_compound Drug Discovery Moiety Pyridinium
Zdroj:	Tetrahedron. 74:2584-2595
ISSN:	0040-4020
Popis:	The halogenation of pyridinium N -(benzoazynyl) aminides with N -halosuccinimides provides a mild and regioselective method to functionalize the negatively charged diazine moiety in most cases. In some examples, however, formation of other products is explained. Finally, alkylation of the exocyclic nitrogen and reduction of the N–N bond provides a simple and straightforward strategy to obtain functionalized N -benzyl-benzoazynyl-α-amines.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::d31a919f4c7acb91683d8e6499229d19 https://doi.org/10.1016/j.tet.2018.03.064 Zobrazit plný text záznamu Full Text from ScienceDirect