Hybrid Imaging PET/CT with Application of 18F-Fluorothymidine in Patients with Head and Neck Carcinoma Undergoing Radiotherapy
| Autor: | Jindrich Finek, Jan Baxa, Ondrej Topolcan, Eva Ferdová, Radovan Vojtíšek, Jiří Ferda |
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| Rok vydání: | 2018 |
| Předmět: |
Cancer Research
PET-CT business.industry medicine.medical_treatment Head and neck cancer Retrospective cohort study General Medicine Pet imaging medicine.disease 030218 nuclear medicine & medical imaging Radiation therapy 03 medical and health sciences 0302 clinical medicine Oncology 030220 oncology & carcinogenesis cardiovascular system Medicine In patient sense organs Tomography business Nuclear medicine circulatory and respiratory physiology Head and neck carcinoma |
| Zdroj: | Anticancer Research. 38:4153-4157 |
| ISSN: | 1791-7530 0250-7005 |
| DOI: | 10.21873/anticanres.12708 |
| Popis: | Aim To introduce the possible benefits of the positron-emission tomography (PET)/computed tomography (CT) with 18F-3'-deoxy-3'-fluorothymidine (18F-FLT) in patients with orofacial carcinomas and its impact to patient management. Materials and methods Thirty-six patients with orofacial squamous cell carcinomas underwent 18F-FLT-PET/CT during radiotherapy. Examinations were performed after administration of 18F-FLT (1.8 MBq/kg) including full-diagnostic CT. Analysis of the radiotherapy effect was performed with possible prospect of repeated and focused irradiation. Results Complete absence of 18F-FLT uptake was found in 20 patients, thus complete response to radiotherapy was reported. Persistence of focal 18F-FLT uptake was observed in 16 patients; in 11 patients, the measured activity was only mild. In five patients, a higher level of 18F-FLT uptake was measured and additional irradiation was performed in defined regions. Repeated follow-up proved complete regression 18F-FLT uptake. Conclusion It was possible to assess the effect of radiotherapy with the use of 18F-FLT-PET/CT and findings are suitable for radiation dose-escalation planning. |
| Databáze: | OpenAIRE |
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