System and methodology to study and stimulate gastric electrical activity in small freely behaving animals

Autor:	Payam Gharibani, Aydin Farajidavar, Sanjeeva Naidu-Naidugari, Joseph C. Sassoon, Jiande Chen, Wahib Alrofati, Amir Javan-Khoshkholgh
Rok vydání:	2019
Předmět:	0301 basic medicine 03 medical and health sciences 030104 developmental biology 0302 clinical medicine business.industry Gastric electrical activity Medicine 030211 gastroenterology & hepatology General Medicine business Neuroscience
Zdroj:	Bioelectronics in Medicine. 2:127-138
ISSN:	2059-1519 2059-1500
DOI:	10.2217/bem-2019-0019
Popis:	Aim: To develop and validate a system that can wirelessly acquire gastric slow waves and deliver electrical pulses to the stomach. Materials & methods: The system is composed of a front-end and a back-end unit connected to a computer, which runs a custom-made graphical user interface. The system was validated on benchtop and in vivo studies. Results: Benchtop validation showed an appropriate frequency response to acquire slow waves. Moreover, the system was able to deliver electrical pulses at amplitudes up to ±10 mA. Slow wave activity recorded from the stomach of rats was in the range of approximately five cycles per minute (cpm). Pulses delivered to the stomach of a rat every 15 s and reduced the activity to 4 cpm during the stimulation period. Conclusion: This study reports the first wireless system and methodology that can be used to acquire slow waves and deliver electrical stimulation to the stomach of small freely behaving animals.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::d317e7ea9cf192f9ac2a3f324a66eaac https://doi.org/10.2217/bem-2019-0019 Zobrazit plný text záznamu