Concise Synthesis of JN403, a Novel Nicotinic Acetylcholine Receptor α7 Selective Agonist

Autor:	Kapa Prasad, Xinglong Jiang, Oljan Repic
Rok vydání:	2009
Předmět:	Agonist chemistry.chemical_classification medicine.drug_class Stereochemistry Organic Chemistry Salt (chemistry) Alcohol n-Butyllithium Neutralization Nicotinic acetylcholine receptor chemistry.chemical_compound Carbamic acid chemistry Yield (chemistry) medicine
Zdroj:	Synthetic Communications. 39:2640-2646
ISSN:	1532-2432 0039-7911
DOI:	10.1080/00397910802663378
Popis:	A three-step method for the synthesis of (S)-(1-aza-bicyclo[2.2.2]oct-3-yl)carbamic acid (S)-1-(2-fluorophenyl)ethyl ester HCl salt (12) was developed, starting from alcohol 3 and resulting in an overall yield of 50%. A key feature of the present study is the need to use a strong base such as n-butyllithium for neutralizing the HCl salt of 5 during the condensation of 4 with 5.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::d30fb143964927cbe8891096b73cacd6 https://doi.org/10.1080/00397910802663378 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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