1,5-Anhydro-d-glucitol 6-phosphate and its use for the specific inhibition of the hexokinase reaction in tissue homogenates

Autor: Richard A. Ferrari, Paul Mandelstam, Robert K. Crane
Rok vydání: 1959
Předmět:
Zdroj: Archives of Biochemistry and Biophysics. 80:372-377
ISSN: 0003-9861
DOI: 10.1016/0003-9861(59)90264-4
Popis: The enzymic preparation of 1,5-anhydro- d -glucitol 6-phosphate and its crystallization as the dicyclohexylamine salt are described. Tests with this compound on enzymes concerned with transformations of glucose 6-phosphate show that it is without influence on glucose 6-phosphate dehydrogenase, that it has a variable influence on phosphoglucomutase, and that, at high concentrations, it inhibits phosphoglucose isomerase to a moderate degree. Tests on heart muscle homogenates show complete inhibition of glucose oxidation but no inhibition of glucose 6-phosphate oxidation by this compound.
Databáze: OpenAIRE