Variability of cytochrome P450 1A2 activity over time in young and elderly healthy volunteers

Autor:	Tabassome Simon, Patrice Jaillon, B. Hamon, Laurent Becquemont, E. Nouyrigat, Christian Funck-Brentano, Y. Chodjania, Jean-Marie Poirier
Rok vydání:	2001
Předmět:	Pharmacology medicine.medical_specialty CYP1A2 Healthy subjects chemistry.chemical_compound Endocrinology chemistry Internal medicine Blood plasma Healthy volunteers medicine Pharmacology (medical) Intraindividual comparison sense organs Young adult Caffeine Paraxanthine
Zdroj:	British Journal of Clinical Pharmacology. 52:601-604
ISSN:	0306-5251
DOI:	10.1046/j.0306-5251.2001.01494.x
Popis:	Aims To assess the age-associated changes over time of plasma paraxanthine/caffeine (PAX/CAF) ratios used as a probe for CYP1A2 activity. Methods Intraindividual and interindividual variabilities in PAX/CAF ratio were compared by phenotyping with caffeine, 16 young and 16 elderly healthy subjects on five occasions. Results PAX/CAF ratio variability was comparable regardless of age (intraindividual CV: 17.6 ± 6% and 16.2 ± 5.9%, interindividual CV: 48.1 ± 2.9% and 42.7 ± 3.6% in young and elderly, respectively). The PAX/CAF ratio was lower in elderly than in young subjects (95% CI for the difference: 0.004, 0.32) but the difference was not significant in nonsmokers compared separately. Conclusions The variability over time of the PAX/CAF ratio is not influenced by age.
Databáze:	OpenAIRE
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