Protection of corneal epithelium by repetitive magnetic stimulation in a rabbit model of dry eye
| Autor: | Noa Avni-Zauberman, Ifat Sher, Zehavit Goldberg, Arie L. Marcovich, Ettel Bubis, Ofra Kalter-Leibovici, Guy Ben Simon, Adi Tzameret, Ygal Rotenstreich |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Exposure keratopathy genetic structures business.industry Stimulation eye diseases chemistry.chemical_compound medicine.anatomical_structure chemistry Ophthalmology medicine Rabbit model Barrier integrity Histopathology In patient sense organs Fluorescein business human activities Corneal epithelium |
| Zdroj: | Ophthalmic Technologies XXXI. |
| DOI: | 10.1117/12.2583382 |
| Popis: | In this preclinical study we demonstrated that treatment with repetitive magnetic stimulation (RMS) protects the epithelial layer in a rabbit model of exposure keratopathy, preventing loss of the epithelial cells and maintaining the function of the corneal barrier under extreme desiccation conditions. A single 15 minutes RMS treatment supported corneal barrier integrity under acute desiccation for 3 months. AS-OCT imaging and histopathology analysis demonstrated the safety of RMS treatment. Our study suggests that repetitive magnetic stimulation may present a novel treatment for protection of corneal epithelium in patients with DES, and may alleviate DES symptoms. |
| Databáze: | OpenAIRE |
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