Abstract P347: Thrombus Age and Volume as Predictors of Recanalization and Functional Outcome in Patients With Cerebral Venous Thrombosis
| Autor: | Enrique Castellanos Pedroza, Miguel Calderón García, Alonso Alvarado Bolaños, Miguel A Barboza, Antonio Arauz, Roberto Toledo Treviño, Vanessa Cano Nigenda, Diana M Manrique, María Fernanda Menéndez-Manjarrez |
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| Rok vydání: | 2021 |
| Předmět: | |
| Zdroj: | Stroke. 52 |
| ISSN: | 1524-4628 0039-2499 |
| Popis: | Background: Cerebral Venous Thrombosis (CVT) is an infrequent type of cerebrovascular disease with variable functional outcomes. Different studies have been carried out to identify such predicting factors. Few studies have focused on imaging findings as predictive factors for recanalization and functional outcome after CVT. We analyzed the association of clot burden with image and functional outcomes in CVT. Methods: This is a retrospective, cross-sectional study of patients with diagnosis of CVT conducted from November 2003 to august 2019. Imaging data was obtained from PACS system and processed with ITK-SNAP1 program for 3D volumetric measurement of the thrombus; through analysis of T1, T2 and SWI sequences the age of the thrombus was determined. Functional outcome was evaluated using the modified Rankin Scale (mRS) at discharge and 3 months after index event. In order to assess the reproducibility of the thrombus measurement method, a second investigator was assigned to perform similar measurements in 10 patients selected randomly. The age and volume of the thrombus to predict recanalization was evaluated through ROC analysis. Results: Twenty-nine patients were studied of which 79.3% were women (n = 23), mean age was 37.79 ± 13.8 years; the superior longitudinal sinus (SLS) was the main sinus affected 44.8% (n = 13) and 44.7% (n = 13) had direct signs on CT study. Mean thrombus volume was 5,463 mm3 ± 6,501 mm3. Regarding the age of the thrombus 72.4% (n = 21) was qualified as acute thrombus with a mean time of 7.21 ± 8.1 days. Age of thrombus demonstrated statistical association with venous sinus recanalization (p = 0.033). Age and volume of the thrombus did not reach statistical significance for functional outcome. The optimal cut-off for the age of the thrombus for complete sinus recanalization in patients with CVT was 4.5 days (Sensitivity of 60% and Specificity of 30%). Conclusion: This is a pilot study that evaluated CVT imaging factors for sinus recanalization and functional outcome. Although volume of the thrombus did not predict recanalization, parenchymal lesions or functional outcome in patients with CVT, acute thrombus age could serve as a predictive factor for venous sinus recanalization which is related to functional outcome in these patients. |
| Databáze: | OpenAIRE |
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