REDUCED CIRCULATING ANGIOGENIC CELLS IN ALZHEIMER DISEASE
| Autor: | Jae-Jun Bahn, Chu K, Oh Mj, Jung Kh, Park Hk, Soon-Tae Lee, Kim M, Lee Sk, Roh Jk, Kim Jh, Kim Dh |
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| Rok vydání: | 2010 |
| Předmět: |
Pathology
medicine.medical_specialty Amyloid business.industry medicine.disease Phenotype Vascular endothelial growth factor Central nervous system disease chemistry.chemical_compound Degenerative disease chemistry mental disorders Toxicity medicine Cancer research Dementia Neurology (clinical) Alzheimer's disease business |
| Zdroj: | Neurology. 74:346-347 |
| ISSN: | 1526-632X 0028-3878 |
| Popis: | I read the article by Lee et al., who reported decreased numbers of circulating angiogenic cells in Alzheimer disease (AD).1 This may be associated with impairment of the blood–brain barrier (BBB) permitting toxic substances such as beta amyloid to penetrate the brain. Brain endothelial cells regulate AD amyloid (Abeta) levels in the neuronal microenvironment. Conversely, Abeta is toxic to neuroendothelial cells, which reduces their survival, yet Abeta(1-42) complexed with Al(3+) or Abeta(1-42)-Al increases the toxicity of neuroendothelial cells.2 Patients with AD have significantly higher levels of serum aluminum than patients with other forms of dementia and age-matched controls.3 Vascular endothelial growth factor (VEGF) phenotypes may also contribute to development of AD. This … |
| Databáze: | OpenAIRE |
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