Relationships between measures of adiposity with subclinical atherosclerosis in patients with type 2 diabetes
| Autor: | Mary E. Comeau, Barry I. Freedman, Donald W. Bowden, Carl D. Langefeld, Jianzhao Xu, J. Jeffrey Carr, S. Carrie Smith, Lynne E. Wagenknecht, Mingxia Yuan, Fang-Chi Hsu, Thomas C. Register, Jasmin Divers |
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| Rok vydání: | 2016 |
| Předmět: |
medicine.medical_specialty
Waist Endocrinology Diabetes and Metabolism Medicine (miscellaneous) 030209 endocrinology & metabolism Type 2 diabetes 030204 cardiovascular system & hematology Nephropathy 03 medical and health sciences 0302 clinical medicine Endocrinology Internal medicine Diabetes mellitus medicine Subclinical infection Nutrition and Dietetics business.industry nutritional and metabolic diseases medicine.disease Obesity Coronary arteries medicine.anatomical_structure cardiovascular system Cardiology business Body mass index |
| Zdroj: | Obesity. 24:1810-1818 |
| ISSN: | 1930-7381 |
| Popis: | Objective Assess cross-sectional relationships between body mass index (BMI), waist circumference (WC), pericardial (PAT), visceral (VAT), and subcutaneous adipose tissue (SAT) volumes with calcified plaque (CP) in African Americans (AAs) and European Americans (EAs) with type 2 diabetes. Methods Computed tomography measured PAT, VAT, SAT, and CP in coronary arteries (CAC), carotid arteries, and aorta. Generalized estimating equations models were fitted to test for associations between adiposity and CP, stratified by ethnicity while accounting for familial correlations. Results AAs (N = 753) vs. EAs (N = 562) had significantly lower PAT and VAT, despite equal or higher BMI. In multivariable models adjusting for age, gender, education, HbA1c, statins, smoking, cardiovascular disease, hypertension, nephropathy, and C-reactive protein, PAT positively associated with presence of CAC in AAs (P < 0.001), not EAs (P = 0.68; ethnicity interaction P < 0.01). Inverse associations were detected between SAT and severity of aorta CP (P < 0.01) in AAs and between BMI, WC, and SAT with severity of aorta CP in all participants. Conclusions Ethnic- and gender-specific differences in BMI, WC, PAT, SAT, and VAT were present in AAs and EAs with diabetes. Only PAT was positively associated with CAC in AAs; paradoxical inverse associations were seen between several other adiposity measures and subclinical cardiovascular disease. |
| Databáze: | OpenAIRE |
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