Evaluation of Pentravan ® , Pentravan ® Plus, Phytobase ® , Lipovan ® and Pluronic Lecithin Organogel for the transdermal administration of antiemetic drugs to treat chemotherapy-induced nausea and vomiting at the hospital
| Autor: | Pascal Odou, Claude Vaccher, Catherine Foulon, Florence Bourdon, Marie Lecoeur, Mostafa Kouach, V. Ultré, L. Leconte |
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| Rok vydání: | 2016 |
| Předmět: |
Nausea
business.industry Pharmaceutical Science 02 engineering and technology Pharmacology 021001 nanoscience & nanotechnology 030226 pharmacology & pharmacy Ondansetron 03 medical and health sciences 0302 clinical medicine Anesthesia medicine Vomiting medicine.symptom 0210 nano-technology Drug carrier business Aprepitant Dexamethasone medicine.drug Transdermal Chemotherapy-induced nausea and vomiting |
| Zdroj: | International Journal of Pharmaceutics. 515:774-787 |
| ISSN: | 0378-5173 |
| Popis: | The objective of this study was to evaluate five commercial ready-to-use transdermal vehicles (Phytobase®, Lipovan®, Pentravan®, Pentravan® Plus and Pluronic Lecithin Organogel (PLO)), for the compounding of three antiemetic drugs (ondansetron, dexamethasone and aprepitant) and their administration in combination to treat chemotherapy-induced nausea and vomiting (CINV) at the hospital. Drugs were individually formulated in these vehicles and in mixture in Pentravan® Plus using different penetration enhancers. Quality control of the forms has demonstrated that formulation process was mastered and convenient for the hospital (time required: 20min). Diffusion experiments through synthetic membranes and pig ear epidermis performed using Franz-type diffusion cells, have shown that the release and permeation process were greater for ondansetron than for dexamethasone and aprepitant, with a release step not limiting. As permeation of aprepitant was too low, it was discarded of the study. When ondansetron and dexamethasone were compounded in combination in Pentravan® Plus, the most efficient vehicle, a permeation decrease was observed. Finally, the use of tween 20 instead of EtOH as chemical enhancer has led to 2-fold factor increase in the flux of dexamethasone, resulting in fluxes convenient for transdermal administration of ondansetron to a child, but insufficient for an adult and for dexamethasone. |
| Databáze: | OpenAIRE |
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