Enhancing catalytic activity of pyridines via para-iminophosphorano substituents

Autor:	C. Adam Dyker, Nicholas A. Richard, Grant D. Charlton
Rok vydání:	2021
Předmět:	010405 organic chemistry Chemistry Organic Chemistry Substituent 010402 general chemistry 01 natural sciences Biochemistry Medicinal chemistry 0104 chemical sciences Catalysis Acylation chemistry.chemical_compound Nucleophile Physical and Theoretical Chemistry
Zdroj:	Organic & Biomolecular Chemistry. 19:9167-9171
ISSN:	1477-0539 1477-0520
Popis:	Four pyridines decorated with π-donating iminophosphorano substituents (R3PN–) in the 4-position were assessed as acylation catalysts. These catalysts display high sensitivity to the groups at phosphorus, with activities that are well correlated to the corresponding Hammett-type substituent constants (σp+), and can achieve superior activity over the most active dialkylamino-substituted pyridines. Iminophosphorano-substituted pyridines represent an easily accessible, tunable, and highly active class of nucleophilic organocatalysts.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::d2f0a182999969e249cef7d80a3897c5 https://doi.org/10.1039/d1ob01630j Zobrazit plný text záznamu