Migration Stimulating Factor (MSF): Its Role in the Tumour Microenvironment
| Autor: | Lateef E. Aljorani, Anne-Marie Woolston, Katerina Kankova, R. P. Keatch, Paul A. Felts, Seth L. Schor, S Perrier, Ana M. Schor, Koji Harada |
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| Rok vydání: | 2021 |
| Předmět: |
Gene isoform
0303 health sciences Messenger RNA biology Chemistry Angiogenesis Cell migration Matrix (biology) Migration-stimulating factor Cell biology Fibronectin 03 medical and health sciences 0302 clinical medicine 030220 oncology & carcinogenesis biology.protein Gene 030304 developmental biology |
| Zdroj: | Advances in Experimental Medicine and Biology ISBN: 9783030731182 |
| DOI: | 10.1007/978-3-030-73119-9_18 |
| Popis: | Migration Stimulating Factor (MSF) is a 70 kDa truncated isoform of fibronectin (FN); its mRNA is generated from the FN gene by an unusual two-stage processing. Unlike full-length FN, MSF is not a matrix molecule but a soluble protein which displays cytokine-like activities not displayed by any other FN isoform due to steric hindrance. There are two isoforms of MSF; these are referred to as MSF+aa and MSF-aa, while the term MSF is used to include both. |
| Databáze: | OpenAIRE |
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