Adjunct cyclosporine therapy for refractory Kawasaki disease in a very young infant
| Autor: | Shouichi Ohga, Hiroko Yamada, Yuno Korenaga, Hideaki Akase, Yoshihiro Azuma, Seigo Okada, Yasuo Suzuki, Midori Wakabayashi-Takahara, Shunji Hasegawa |
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| Rok vydání: | 2015 |
| Předmět: |
Coronary artery aneurysm
Pediatrics medicine.medical_specialty biology business.industry medicine.disease Young infants 03 medical and health sciences 0302 clinical medicine medicine.anatomical_structure Refractory 030225 pediatrics Pediatrics Perinatology and Child Health biology.protein medicine Kawasaki disease 030212 general & internal medicine Antibody Cyclosporine therapy Adverse effect business Artery |
| Zdroj: | Pediatrics International. 58:295-298 |
| ISSN: | 1328-8067 |
| Popis: | Herein we describe the case of a 6-week-old boy who developed complete Kawasaki disease (KD). The cytokine profile and activation of monocytes and subsequent T cells matched the typical feature of refractory KD. The patient received a total of three courses of i.v. immunoglobulin (IVIG), but did not achieve clinical relief. Adjunctive therapy with oral cyclosporine A (CsA) led to prompt defervescence. This was continued for 7 days without serious adverse events. Coronary artery dilatations regressed within 3 months of follow up. KD infants |
| Databáze: | OpenAIRE |
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