| Autor: |
Dalia A. Elaty Mostafa, Maha K. A. Khalifa, Sameh. S. Gad |
| Rok vydání: |
2020 |
| Předmět: |
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| Zdroj: |
International Journal of Applied Pharmaceutics. :86-93 |
| ISSN: |
0975-7058 |
| DOI: |
10.22159/ijap.2020v12i2.36812 |
| Popis: |
Objective: Zolmitriptan, a class of antidepressant drugs with poor bioavailability due to its first-pass metabolism. The aim of this study was to improve systemic bioavailability and explore the brain targeting impact of nasal Zolmitriptan (Zol) solid lipid nanoparticles (SLNs) gel for migraine treatment. Methods: Stearic acid and cholesterol used as solid lipid and lecithin as a surfactant, emulsion solvent evaporation technique was used to produce Zolmitriptan SLNs. (Zol) SLNs were characterized for particle size, percent entrapment efficiency and in vitro drug release. Formula S6 showed greater percent entrapment efficiency (PEE), adequate particle size and sustained drug release behavior. Formula S6 was integrated into HPMC gel (3%) to prepare nasal gel. Zol SLN nasal gel was subjected to histopathological study to ensure brain targeting. Results: It was observed that all prepared Zol SLNs were in the nano-sized range with a polydispersity index of |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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