Prognostic Significance of Comparison of Clinical Indicators with Manifestations of Genetic Polymorphism of Glutathione-S-Transferases in Non-Small Cell Lung Cancer
| Autor: | N. V. Chebotareva, Alena Mikhalenka, Mikhail N. Shapetska, Svetlana G. Pashkevich, E. V. Krupnova, Alexander V. Prokhorov, Anna Shchayuk |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0106 biological sciences
medicine.medical_specialty Lung biology business.industry medicine.disease 01 natural sciences Gastroenterology 03 medical and health sciences GSTP1 0302 clinical medicine Glutathione S-transferase medicine.anatomical_structure 010608 biotechnology 030220 oncology & carcinogenesis Internal medicine Genotype medicine biology.protein Carcinoma Adenocarcinoma Lung cancer business Survival rate |
| Zdroj: | Journal of Cancer Therapy. :962-973 |
| ISSN: | 2151-1942 2151-1934 |
| DOI: | 10.4236/jct.2018.912080 |
| Popis: | The article presented the results of comparison of polymorphic variants of the genes GSTM1, GSTT1, GSTP1 and clinical manifestations of non-small cell lung carcinoma. The association of the genotype GSTT1 (del) with the risk of developing squamous cell lung cancer has been revealed (OR = 2.54 CI: 1.13 - 5.72, p = 0.035). Analysis of patient survival rate (n = 173) in groups of various histological types of lung cancer showed that in the group of squamous cell lung cancer (n = 91) in patients with genotype GSTT1 (del), the survival rate median was significantly higher—84 months (95% CI 12.4 - 155.7) than in patients with the genotype GSTT1 (+)—36 months (95% CI 25.2 - 46.8, p = 0.045). In contrast, in the adenocarcinoma group (n = 82), the survival rate median in patients with the genotype GSTT1 (del) was 19 months. (95% CI 6.2 - 33.5), and in patients with genotype GSTT1 (+)—67 months (95% CI 50.1 - 84.0), which is the basis for continuing this comparison in an additional group of testees, as the sampling did not achieve the reliability of p = 0.12. Hypothetically, these differences may be due to differences in the gender composition of squamous cell lung cancer and adenocarcinoma and the involvement of GST enzymes in the metabolism of estrogens in adenocarcinoma in women and other hormonal background and reactivity of the male body with squamous cell carcinoma. Further research and subsequent analysis of the results will be aimed at confirming this hypothesis. |
| Databáze: | OpenAIRE |
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