| Autor: |
Kpan Nestor Gono, Abale Anatole Toty, Gilles-Alex Pakora, Dodehe Yeo, You Christiane Essoh, Kacou Adele NDouba |
| Rok vydání: |
2021 |
| Předmět: |
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| Zdroj: |
Advances in Bioscience and Bioengineering. 9:75 |
| ISSN: |
2330-4154 |
| Popis: |
Natural products and their derivatives have always been the major source of bioactive compounds used for the treatment of new and existing diseases. The present study was carried out to investigate the antibacterial activity of the crude extract of an endophytic fungus isolated from the leaves of Picralima nitida, a medicinal plant of the Apocynaceae family and to isolate and identify the molecule responsible for this activity. Thus, secalonic acid B isolated from the crude extract of an endophytic fungus was tested on six (06) pathogenic bacterial strains by agar diffusion method for strain susceptibility test. And the liquid diffusion test was used to determine the antibacterial parameters (BMC and MIC). The isolated endophytic fungus was identified by molecular biology methods as a strain of Clonotachys sp. The antibacterial test performed with the Clonotachys sp. extract showed inhibitory activity on Staphylococcus aureus (ATCC 25923, 931/18 and 934/18) and Klebsiella pneumoniae (815/18) strains with inhibition diameters ranging from 18.43±1.05 to 7.56±0.73 mm. This extract has a bactericidal power on these strains. As for the secalonic acid B isolated from this fungal extract, it also showed efficacy against Staphylococcus aureus and Klebsiella pneumoniae with bactericidal power. The endophytic fungus Clonotachys sp. is therefore a potential source of antibacterial compounds. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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