Gentamicin sulfate attachment and release from anodized Ti-6Al-4V orthopedic materials

Autor:	R. G. Volz, Srini Raghavan, D. S. Dunn
Rok vydání:	1993
Předmět:	Materials science Anodizing Biomedical Engineering Oxide chemistry.chemical_element Biomaterial Microporous material Biomaterials chemistry.chemical_compound Gentamicin Sulfate chemistry Chemical engineering Porosity Phosphoric acid Biomedical engineering Titanium
Zdroj:	Journal of Biomedical Materials Research. 27:895-900
ISSN:	1097-4636 0021-9304
DOI:	10.1002/jbm.820270708
Popis:	A novel method has been developed to attach, retain, and release antibiotics from titanium based materials. This technique consists of forming porous surface coatings by anodizing and using the surface chemical properties of the oxide coatings to attach antibiotics. Coatings with pores in the size range 0.1–0.5 μm have been formed in acid solutions. The attachment and retainment of gentamicin sulfate, a cationic antibiotic, to the coatings has been investigated using microbiological methods. In vitro test results have shown that the duration of antimicrobial activity on the surface of anodized materials is dependent on the porosity and isoelectric point of the coatings. Using microporous oxide coatings formed in phosphoric acid solutions, it has been found that antimicrobial activity could be retained for more than 2 weeks. © 1993 John Wiley & Sons, Inc.
Databáze:	OpenAIRE
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