Modern approach to diagnosis of inherited functional platelet disorders
| Autor: | S.A. Plyasunova, P.А. Zharkov, E.A. Seregina, Anastasia A. Ignatova, D.V. Fedorova |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
medicine.medical_specialty
Light transmission education.field_of_study Heterogeneous group business.industry Platelet disorder Immunology Population Diagnostic algorithms Hematology Hemorrhagic diseases Oncology Pediatrics Perinatology and Child Health medicine Immunology and Allergy Intensive care medicine business education Surgical interventions Clinical evaluation |
| Zdroj: | Voprosy gematologii/onkologii i immunopatologii v pediatrii. 16:83-95 |
| ISSN: | 2414-9314 1726-1708 |
| Popis: | Inherited functional platelet disorders (IFPD) are very heterogeneous group of hemorrhagic diseases that are difficult to diagnose. Prevalence of IFPD in general population is probably underestimated. In most cases IFPD cause mild to moderate bleeding symptoms in everyday life but may result in life-threating bleeding after trauma and surgical interventions. Rational diagnostic approach is critical to prevent these complications. Data on diagnostic algorithms as well as on benefits and disadvantages of specific laboratory methods are presented in this review. Approach to clinical evaluation is also reviewed with particular attention to bleeding assessment tools. The main emphasis is made on light transmission aggregometry, measurement of platelet granules content and release, flow cytometry. Problems of standardization of platelet functional tests are outlined. Diagnostic algorithms are applied according to the up to date recommendations of International Society on Thrombosis and Haemostasis. |
| Databáze: | OpenAIRE |
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