Retroperitoneal dedifferentiated liposarcoma with huge cystic degeneration: A case report
| Autor: | Yoshizo Kimura, Eisuke Shiba, Chisachi Kubo, Hiroshi Harada, Kei Yabuki, Kazuyoshi Uchihashi, Masanori Hisaoka, Mao Jotatsu, Atsuji Matsuyama, Toshiro Ogata, Yojiro Tsuda |
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| Rok vydání: | 2017 |
| Předmět: |
Pathology
medicine.medical_specialty business.industry medicine.medical_treatment General Medicine Liposarcoma Cystic Change medicine.disease Nephrectomy Pathology and Forensic Medicine Adipose capsule of kidney 03 medical and health sciences 0302 clinical medicine medicine.anatomical_structure 030220 oncology & carcinogenesis Subserosa Medicine 030211 gastroenterology & hepatology Differential diagnosis business Renal sinus Mesentery neoplasms |
| Zdroj: | Pathology International. 67:264-268 |
| ISSN: | 1320-5463 |
| DOI: | 10.1111/pin.12525 |
| Popis: | Prominent cyst formation is an unusual feature of liposarcoma. We report here a case of dedifferentiated liposarcoma with huge cystic change without preoperative chemo- or radiation therapy. The lesion arose in the retroperitoneum juxtaposed to the right kidney of a 67-year-old woman. She underwent a surgical removal of the retroperitoneal cyst. The cystic tumor contained 1600 mL of old bloody fluid, and its wall was composed of edematous, inflamed or sclerosing fibrous tissue with fatty tissue containing abundant atypical stromal cells, which were immunohistochemically positive for MDM2 and CDK4, and demonstrated MDM2 gene amplification by fluorescence in situ hybridization. The wall was contiguous to an atypical lipomatous nodule located in the mesentery. The following surgical specimens of the right hemicolectomy and right nephrectomy revealed atypical cells infiltrating into the subserosa of the colon and the perirenal fat tissue or that in the renal sinus. This case indicates that well differentiated or dedifferentiated liposarcoma should be also considered as a differential diagnosis of perirenal cystic mass. |
| Databáze: | OpenAIRE |
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