Inflammation fails to explain young—Old difference in hyperoxia lethality
| Autor: | Andrew T. Canada |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
chemistry.chemical_classification
Hyperoxia Reactive oxygen species medicine.medical_specialty Lung Health Toxicology and Mutagenesis chemistry.chemical_element Inflammation Lung injury Biology Toxicology medicine.disease Oxygen Endocrinology medicine.anatomical_structure chemistry Internal medicine Immunology medicine Macrophage medicine.symptom Oxygen toxicity |
| Zdroj: | Inhalation Toxicology. 7:1247-1256 |
| ISSN: | 1091-7691 0895-8378 |
| DOI: | 10.3109/08958379509029715 |
| Popis: | The inflammation that accompanies oxygen toxicity to the lung is believed to magnify the damage and to be a significant factor in determining the ultimate extent of lung injury. The mechanism proposed for the increased lung damage associated with inflammation is the release of reactive oxygen species by leukocytes (PMNs) and macrophages that are recruited to the damaged lung. In an earlier study, when 2-mo and 27-mo male Fischer 344 rats were exposed to >98% oxygen, a significant difference was found in survival. The old rats lived approximately two times as long as the young rats. This study explored the hypothesis that the age-related lethality difference was due to a faster onset and greater extent of inflammation in the lungs of young rats than old. Following 55 h of exposure to >98% oxygen, bronchopulmonary lavage demonstrated no differences in protein or in neutrophil or macrophage composition. In addition, there was no significant difference in whole lung myeloperoxidase activity between th... |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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