| Autor: |
Cristina Machado Bragança de Moraes, Denizar Mello, Leticia Paranhos De Oliveira, Shanna Bitencourt, Julia Schmid, Eduardo Caberlon, Gabriela Acevedo Ferreira, Bruno de Souza Basso, Fernanda Cristina de Mesquita, Vinicius Lorini, Jarbas Rodrigues de Oliveira, Gabriela Silva |
| Rok vydání: |
2014 |
| Předmět: |
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| Zdroj: |
Cell Biology International. 38:526-530 |
| ISSN: |
1065-6995 |
| Popis: |
(+)-Catechin is a type of catechin present in large amounts in acai fruits and cocoa seeds. Besides its antioxidant and anti-inflammatory activities, little is known about its effects in the liver, especially during hepatic fibrosis. We report here the effects of (+)-catechin on hepatic stellate cells. (+)-Catechin induced quiescent phenotype in GRX cells, along with an increase in lipid droplets. Proliferator-activated receptor γ mRNA expression was upregulated, whereas type I collagen mRNA expression was downregulated. Pro-inflammatory cytokines were not influenced by (+)-catechin, whereas the levels of interleukin 10 were significantly increased. The data provide evidence that (+)-catechin can reduce hepatic stellate cell activation. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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