Implementation of ultraviolet solid-phase spectrophotometry by use of derivative techniques

Autor:	M. Carmen Valencia, Juan J. Berzas-Nevado, L. Fermín Capitán-Vallvey, Ignacio de Orbe
Rok vydání:	1993
Předmět:	Chromatography medicine.diagnostic_test Derivative medicine.disease_cause Biochemistry Analytical Chemistry Sulfathiazol Absorbance chemistry.chemical_compound chemistry Spectrophotometry Phase (matter) medicine Environmental Chemistry Thiazole Spectroscopy Derivative spectroscopy Ultraviolet
Zdroj:	Analytica Chimica Acta. 282:75-80
ISSN:	0003-2670
DOI:	10.1016/0003-2670(93)80353-m
Popis:	A spectrophotometric method for the simultaneous determination of sulphathiazole and sulphametazine based on fourth-derivative solid-phase spectrophotometry is proposed. Both sulphonamides were fixed on a dextran-type cation-exchange gel at pH 2.5. The absorbance on the gel, packed in a 1-mm silica cell, was measured directly. The method does not require any separation step. The range of application is between 0.20 and 12.00 μg ml−1 for sulphathiazole and between 0.20 and 15.00 μg ml−1 for sulphametazine. The acuracy and precision of the method are reported. The method was applied for the determination of sulpha thiazole and sulphametazine in synthetic mixtures and pharmaceuticals.
Databáze:	OpenAIRE
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