Current use of animal models of disease for nonclinical safety testing
| Autor: | Diann Blanset, Julie Hutt, Sherry Morgan |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
education.field_of_study Potential risk Population Nonclinical safety Disease 010501 environmental sciences Toxicology 01 natural sciences Review article 03 medical and health sciences 030104 developmental biology Human disease Risk analysis (engineering) Business education 0105 earth and related environmental sciences |
| Zdroj: | Current Opinion in Toxicology. :11-16 |
| ISSN: | 2468-2020 |
| DOI: | 10.1016/j.cotox.2020.02.005 |
| Popis: | Interest in the use of animal models of human disease has been increasing both within pharmaceutical companies and regulatory authorities, as evidenced by several recent publications and inclusion of recommendations for the use of these models in regulatory guidances. While the use of conventional or healthy animal models will continue to be a central component of safety evaluation, there are certain instances in which the use of animal models is critical for the understanding of potential risk for a diseased population. This review article provides highlights of the use of animal models of disease and provides examples of recent uses of animal models in the elucidation of safety considerations for humans, focusing on instances in which the models have been utilized in regulatory filings. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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