Synthesis and Characterization of a New Class of Triazoles Containing Bicyclic Silaheterocycles

Autor: Tengjiao Wang, Hyeon Mo Cho, Myong Euy Lee
Rok vydání: 2017
Předmět:
Zdroj: ChemistrySelect. 2:3673-3675
ISSN: 2365-6549
DOI: 10.1002/slct.201700273
Popis: A new class of bicyclic silaheterocycles, 6,6-dimethyl-2-aryl-6,7-dihydro-5H-[1,2,4]triazolo[5,1-b][1,3,5]thiazasilines, which could be developed as potential sila-drugs. The reactions of several 3-aryl-5-mercapto-1,2,4-triazoles with bis(chloromethyl)dimethylsilane under basic conditions gave high yields of bicyclic products. Reaction, product workup and isolation were streamlined without requiring an anhydrous solvent, inert gas or chromatographic purification. The products were structurally characterized by single-crystal X-ray diffraction.
Databáze: OpenAIRE