On-line monitoring of a crystallization process

Autor: Graeme White, A F Thomas, Kevin J. Roberts, Derek Wilkinson, Norbert Herrmann, Richard J. Tweedie, Robert Jack, Patricia Mougin
Rok vydání: 2003
Předmět:
Zdroj: AIChE Journal. 49:373-378
ISSN: 1547-5905
0001-1541
DOI: 10.1002/aic.690490209
Popis: The application of ultrasonic spectroscopy for particle-size measurements was investigated during the batch crystallization of (L)-glutamic acid α-polymorph from an aqueous solution. The technique, based on measurements of the attenuation of ultrasonic waves through the suspension, was applied using a prototype ultrasonic spectrometer with a flow-through cell. High-precision measurements of ultrasonic attenuation in the frequency range 7-110 MHz were performed, the deconvolution of which enabled in-process measurement of crystal size distribution and solid concentration throughout the crystallization process. In addition to evincing secondary nucleation, growth and crystal breakage on-line in real time, the experimental results were used to obtain kinetic parameters essential for process design, including secondary nucleation rate and growth rate.
Databáze: OpenAIRE
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