| Autor: |
Carlos Simón Adiego, Leire Azcárate Perea, Ignacio Garutti Martínez, Guillermo González-Casaurrán, Elena Vara Ameigeiras, Cruz García Martín, Jesus Isea de la Viña, Javier Casanova Barea, Ana Giráldez López, Beatriz Martín Piñeiro, Federico González-Aragoneses |
| Rok vydání: |
2011 |
| Předmět: |
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| Zdroj: |
Archivos de Bronconeumología (English Edition). 47:283-289 |
| ISSN: |
1579-2129 |
| DOI: |
10.1016/j.arbr.2011.02.002 |
| Popis: |
Introduction Ischemia–reperfusion (IR) lung injury has been investigated extensively on clinical and experimental models of cold ischemia. However, relatively few studies examine the detailed biochemical changes occurring during normothermic (warm) IR. Animals and methods Six large-white pigs underwent a lung autotransplant which entailed left pneumonectomy, ex situ cranial lobectomy, caudal lobe reimplantation and its reperfusion for 30 min. Throughout the procedure, several parameters were measured in order to identify hemodynamic, gasometric and biochemical changes. Non-parametric statistical analyses were used to compare differences between periods. Results After ischemia, a significant increase (p Conclusions An experimental model of normothermic lung IR injury is presented and detailed changes in hemodynamic, gasometric and biochemical parameters are shown. Both the model and the studied parameters may be clinically useful in future investigations testing new therapies to prevent normothermic IR induced lung injury. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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