Factors Affecting Short- and Long-Term Outcome of a Short Therapeutic Trial with Cisapride in Dyspeptic Patients: General Discussion

Autor:	R. Rambaldo, B. Hazelhoff, P. M. Heyse
Rok vydání:	1993
Předmět:	Response rate (survey) medicine.medical_specialty business.industry Gastroenterology Therapeutic trial Patient population Cisapride Internal medicine medicine In patient Previously treated business Moderate Response Symptom score medicine.drug
Zdroj:	Scandinavian Journal of Gastroenterology. 28:15-24
ISSN:	1502-7708 0036-5521
Popis:	In a Dutch general practice trial conducted in 599 patients with symptoms of dyspepsia, the response to 5 mg cisapride three times daily was rated excellent or good in 61 % of patients at week 2. On increasing the dose to 10 mg three times daily in 132 patients with poor to moderate response, the result at the end of treatment was rated as good or excellent in 45% of these patients, and the mean symptom score further decreased significantly (p 4 years). Cisapride also proved effective in patients previously treated with prokinetic agents (72% response rate), antacids (66%) and H2-receptor antagonists (48%). On long-term follow-up, dyspepsia relapse rates among the total patient population (n = 357) and the patient sample fully ‘cured’ after 4 weeks of cisapride (n = 226) were respectivel...
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::d29424889a8343b7e14b9209c22eec52 https://doi.org/10.3109/00365529309098324 Zobrazit plný text záznamu