Залежність літогенності жовчі від показників вуглеводного та ліпідного обмінів у хворих на цукровий діабет типу 2 із хронічним некалькульозним холециститом
| Autor: | D. R. Andriychuk, O. I. Fediv, N.V. Pashkovska, Yu. F. Marchuk |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Cholesterol business.industry Gallbladder Type 2 Diabetes Mellitus Blood lipids Lipid metabolism medicine.disease Gastroenterology Chronic Acalculous Cholecystitis chemistry.chemical_compound medicine.anatomical_structure Blood serum chemistry Internal medicine Diabetes mellitus medicine lipids (amino acids peptides and proteins) business |
| Zdroj: | INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (Ukraine). 15:202-209 |
| ISSN: | 2307-1427 2224-0721 |
| DOI: | 10.22141/2224-0721.15.3.2019.172105 |
| Popis: | Background. The purpose of the study is to identify the features of changes in bile homeostasis and major stone-forming substrates in chronic acalculous cholecystitis and type 2 diabetes mellitus (DM). Materials and methods. The clinical examination was performed in 60 patients with type 2 DM and chronic acalculous cholecystitis, 60 individuals with chronic acalculous cholecystitis alone and 20 apparently healthy persons. A thorough examination was carried out using generally accepted clinical, laboratory, biochemical, instrumental methods. The blood lipids and the gallbladder portion of bile have been determined. Results. In patients with chronic acalculous cholecystitis on the background of type 2 DM, there was an increase in the levels of total lipids (by 1.61 times in the blood), cholesterol (by 2.04 times in the blood and 1.62 — in bile), bile acids (by 4.4 times in the blood) and their decrease in bile (by 1.34 times), an increase in triacylglycerols (by 3.09 times in the blood), low-density lipoproteins (by 1.2 times in the blood) and a decrease in the content of high-density lipoproteins (by 1.98 times in the blood) and phospholipids (by 1.38 times in the blood and 1.48 — in bile), as well as a decrease in the two-component ratio of phospholipids/cholesterol (by 1.8 times) and bile acids/cholesterol (by 1.9 times), an increase in the three-component Isaxone index (by 1.85 times), indicating a significant imbalance of lipid metabolism as a predictor of the gallstone formation in this category of patients (p |
| Databáze: | OpenAIRE |
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