A novel anthracene-based fluorescent colorimetric sensor for the simple naked-eye diagnosis of methylmalonic aciduria
| Autor: | Junko Fujimoto, Shoichiro Goto, Youtaro Honda, Moeno Okumura, Riho Mabuchi, Hidekazu Miyaji |
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| Rok vydání: | 2017 |
| Předmět: |
Anthracene
Chromatography 010405 organic chemistry Organic Chemistry Molecular sensor Methylmalonic acid Malonic acid 010402 general chemistry Photochemistry 01 natural sciences Biochemistry Fluorescence 0104 chemical sciences chemistry.chemical_compound chemistry Methylmalonic aciduria Succinic acid Drug Discovery Naked eye |
| Zdroj: | Tetrahedron Letters. 58:3623-3627 |
| ISSN: | 0040-4039 |
| Popis: | A novel molecular sensor using anthracene bearing two amidopyridines emits blue fluorescence in the presence of succinic acid and green fluorescence in the presence of malonic acid, and its fluorescence intensity increased upon binding. Using this molecular sensor, we succeeded in detecting the difference of one carbon atom between succinic acid and malonic acid with the naked-eye. Furthermore, when methylmalonic acid was dissolved in urine to provide a model system for methylmalonic aciduria, the fluorescence changed from blue to green, and methylmalonic acid was successfully detected with the naked-eye. |
| Databáze: | OpenAIRE |
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