Die Bedeutung axonaler Pathologie für das Konzept der Neurodegeneration bei der Multiplen Sklerose

Autor:	J. Bader, Stefanie Kuerten, C. C. Kaiser, K. Addicks, Mascha S. Recks, Michael Schroeter, Gereon R. Fink
Rok vydání:	2011
Předmět:	business.industry Multiple sclerosis Axonal pathology Neurodegeneration Inflammation Disease medicine.disease Psychiatry and Mental health Neurology Immunology medicine Neurology (clinical) medicine.symptom business Neuroscience Pathological
Zdroj:	Fortschritte der Neurologie · Psychiatrie. 79:161-170
ISSN:	1439-3522 0720-4299
Popis:	In spite of tremendous scientific effort, the mechanisms underlying multiple sclerosis (MS) still remain to be elucidated. The prevalent pathogenetic concept adheres to the assumption of a strict hierarchical sequence of the triad inflammation, demyelination and axonal damage. However, recent studies have provided evidence that axonal pathology can occur independently of inflammation and demyelination. The present article critically re-evaluates the traditional paradigm of MS pathology. Potential cellular, humoral and metabolic mechanisms of axonal pathology are delineated and the development of isolated axonal damage is assessed. A better understanding of the pathological processes underlying MS is likely to result in an improvement of current therapeutic strategies. These should not only target the inflammatory, but also the neurodegenerative component of the disease.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::d281efb6646f4278c8df909c572fa547 https://doi.org/10.1055/s-0029-1246014 Zobrazit plný text záznamu