Matrix Chemistry Controlling Stem Cell Behavior
| Autor: | Lakshmi S. Nair, Christina Klecker |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Cell growth Chemistry Cell Nanotechnology 02 engineering and technology Matrix (biology) 021001 nanoscience & nanotechnology Stem cell niche Cell biology Extracellular matrix 03 medical and health sciences 030104 developmental biology medicine.anatomical_structure medicine Tissue specific Stem cell 0210 nano-technology |
| DOI: | 10.1016/b978-0-12-802734-9.00013-5 |
| Popis: | The key to unlocking the vast potential of stem cells' regenerative capacity has long been buried in the complicated labyrinth in which they reside, known as the extracellular matrix (ECM), an essential component of the stem cell niche. Within the past two decades, we have transitioned from believing that the ECM is a passive foundation for cell growth, to our current understanding of the dynamic and responsive meshwork that facilitates tissue development. The composition and structure of the ECM is highly tissue specific as the unique matrix provides the appropriate physical, biological, and chemical signals to optimize cell and tissue functions. This chapter will focus on matrix chemistry and recent advances which demonstrate how they engage with stem cells to modulate their behavior. |
| Databáze: | OpenAIRE |
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