Generalized exanthematous pustolosis: a severe cutaneous drug eruption
| Autor: | Bertoldo, Francesca, Cerica, Alessandra, Barbaccia, Vincenzo, Moggio, Erica, Ciocca, Olga |
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| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| DOI: | 10.6092/2039-1404.124.805 |
| Popis: | Acute generalized exanthematous pustolosis (AGEP) is a severe cutaneous drug eruption, characterized by acute, nonfollicular sterile pustoles on a background of edematous erytema. The clinical presentation is inconstant and polymorphous, with difficult differential diagnosis with other severe generalized skin eruptions. A 70-year-old man developed a generalized exfoliative dermatite due to treatment with hidroxychloroquine for polyarthralgia. Histopathologic examination of a skin biopsy allowed a diagnosis of AGEP. Cyclosporin A treatment induced rapid resolution of the dermatosis. The relationship between AGEP and drug-induced generalized pustular psoriasi is matter of debate, due to the observed occurrence of AGEP in patient with psoriasis or psoriatic arthritis. Bollettino della Società Medico Chirurgica di Pavia, Vol 124, N° 1 (2011) |
| Databáze: | OpenAIRE |
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