Abstract 149: Type Viii Collagen Increases The Risk Of Arteriovenous Fistula Failure In End-stage Kidney Disease Patients
| Autor: | Laisel Martinez, Miguel Rojas, Marwan Tabbara, Simone Pereira-Simon, Nieves Santos Falcon, Mohd A Rauf, Zachary Zigmond, Roberto I Vazquez Padron |
|---|---|
| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Arteriosclerosis, Thrombosis, and Vascular Biology. 42 |
| ISSN: | 1524-4636 1079-5642 |
| Popis: | Introduction: The arteriovenous fistula (AVF) is the lifeline for patients with end-stage kidney disease (ESKD) requiring hemodialysis therapy. The mechanism of “arterialization”, by which a vein transforms into an AVF after anastomosis, is one of the most understudied transformative processes in vascular biology despite the urgent need for new interventions to facilitate and accelerate fistula usability to improve the life of these patients. Hypothesis: Dysregulation of type VIII collagen biosynthesis increases the risk for failure in newly created AVFs Methods and Results: We first deciphered the transcriptional transformation of the pre-access vein after arterial anastomosis using paired venous samples from 38 CKD patients undergoing surgeries for two-stage AVF creation. A total of 3,637 transcripts were differentially expressed (DE) between veins and AVFs in pairwise analyses (log2FC ≥ 1 or ≤ -1, FDR Conclusions: Vascular accumulation of type VIII collagen in the AVF wall after anastomosis strongly increases the risk of failure. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|