Presence of an intrastrain cross-reactive idiotype on A/J antibodies of the IgE class specific for the p-azophenylarsonate group
| Autor: | T Hirano, S Kojima, N Hirayama, M J Nelles, T Inada, A Nisonoff, Z Ovary |
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| Rok vydání: | 1983 |
| Předmět: | |
| Zdroj: | The Journal of Immunology. 130:1300-1302 |
| ISSN: | 1550-6606 0022-1767 |
| DOI: | 10.4049/jimmunol.130.3.1300 |
| Popis: | An intrastrain cross-reactive idiotype, CRIA, is associated with a large proportion of the anti-p-azophenylarsonate (anti-Ar) antibodies of A/J mice. The present experiments, in which the methods of direct and reverse passive cutaneous anaphylaxis (RPCA) were used, indicate that IgE anti-Ar antibodies are produced in A/J mice upon stimulation with a protein-Ar conjugate and that a large proportion of these antibodies express CRIA. The use of monoclonal anti-CRIA for RPCA eliminated the strong nonspecific reactions previously observed. The results provide a basis for studying factors that regulate the switch to IgE biosynthesis during an immune response. |
| Databáze: | OpenAIRE |
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