Antipyretic Effect of Celery (Apium graveolens.) Extracts in Mice

Autor:	R. Mitic, M. Bursac, Mira Popovic, Biljana Kaurinovic, Vida Jakovljevic
Rok vydání:	2006
Předmět:	Pharmacology Apiaceae Chloroform biology Traditional medicine business.industry Ethyl acetate Pharmaceutical Science Apium graveolens General Medicine Pharmacognosy biology.organism_classification Yeast chemistry.chemical_compound Antipyretic Effect Complementary and alternative medicine chemistry Drug Discovery Molecular Medicine Medicine Antipyretic business medicine.drug
Zdroj:	Pharmaceutical Biology. 44:581-584
ISSN:	1744-5116 1388-0209
DOI:	10.1080/13880200600896801
Popis:	Extracts of celery (Apium graveolens. L.; Apiaceae) leaves prepared in solvents of different polarity, viz., ether, chloroform, ethyl acetate, n.-butanol, and water, were used to study their antipyretic effect in mice. Experiments were conducted on white laboratory mice divided into five groups. On the first day of the experiment, their rectal temperatures were measured every 30 min during 5 h (basal temperature). On the second day, the animals were given 12% yeast suspension to induce a pyrogenic effect and on the third day the same dose of yeast and the appropriate celery extract, and the rectal temperatures were measured in the same way as basal temperature. By plotting the measured temperatures versus time, the corresponding areas-under-the-curve (AUC) were obtained for each group of animals. The AUC values were used to determine statistically significant differences between them. The results showed that extracts of celery leaf decreased (annuled) the pyrogenic effect of 12% yeast suspension.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::d2560a43073f2056fbed5378036ee947 https://doi.org/10.1080/13880200600896801 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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