| Popis: |
In search of new anticancer agents with improved efficacy, we designed and synthesized novel hybrid series of isonicotinamide and diaryl urea motifs (R1-R9). Design of series compounds carried out using docking study by Autodock vina tool. Binding energy (more than -9.7 kcal/mol) calculated using Autodock vina against Raf kinase (PDB: 4DBN). All the synthesized compounds were evaluated for them in vitro anticancer activity against MCF-7 cell line. The anticancer activities of the synthesized compounds were also carried. Some of the compounds (R1, R8, R9) showed better activities towards MCF-7 cell line by MTT assay. |
