ERYTHROMYCIN IN THE TREATMENT OF DIPHTHERIA AND DIPHTHERIA CARRIER STATE

Autor:	W. B. Gamble, C. H. Zemp, M. W. Beach, Margaret Q. Jenkins
Rok vydání:	1955
Předmět:	Chlortetracycline medicine.drug_class business.industry Diphtheria Antibiotics Erythromycin medicine.disease complex mixtures Microbiology Macrolide Antibiotics Penicillin Streptomycin Pediatrics Perinatology and Child Health medicine Antitoxin business medicine.drug
Zdroj:	Pediatrics. 16:335-344
ISSN:	1098-4275 0031-4005
DOI:	10.1542/peds.16.3.335
Popis:	The treatment of acute diphtheria has not been drastically changed by the use of antibiotics. Antitoxin remains the primary form of therapy. However, the eradication of virulent diphtheria bacilli from the upper respiratory tract of patients with the active disease and of carriers is of considerable importance in the control of the disease. Streptomycin is effective in vitro and in infections produced experimentally but it has not been clinically evaluated in acute diphtheria or in the carrier state. Chlortetracycline, chloramphenicol, and oxytetracyline, although active against the causative organisms, have not had sufficient clinical trial to permit evaluation in the control of diphtheria and the carrier state. Penicillin eradicates C. diphtheriae from the nasopharynx in 75 per cent of patients within a period of 3 to 4 days. In this study erythromycin eradicated the C. diptheriae from the nose and throat in all of the cases in an average of 2 days in the active cases and in an average of 3 days in the carrier state. In the treatment of diphtheria erythromycin appears on the basis of the present and of previous studies to be the most promising antibiotic developed to date. Erythromycin is advocated as an adjunct to and not as a substitute for antitoxin in the treatment of acute diphtheria.
Databáze:	OpenAIRE
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