EFFICACY, SAFETY, AND COST-EFFECTIVE ANALYSIS OF LOW-DOSE ETORICOXIB AND ADD-ON PARACETAMOL VERSUS THERAPEUTIC DOSE ETORICOXIB FOR PAIN IN PATIENTS AFTER TOOTH EXTRACTION: A RANDOMIZED INTERVENTIONAL DOUBLE-BLIND STUDY

Autor:	KOTHARI SAROJ, BANSAL HARESH, PAHARIA YOGENDRA
Rok vydání:	2022
Předmět:	Pharmacology Pharmaceutical Science Pharmacology (medical)
Zdroj:	Asian Journal of Pharmaceutical and Clinical Research. :46-50
ISSN:	2455-3891 0974-2441
Popis:	Objectives: The objectives of the study were to study the efficacy, safety, and cost-effective analysis of low-dose etoricoxib and add-on paracetamol versus therapeutic dose etoricoxib in patients who experienced pain after tooth extraction. Methods: Patients were recruited and randomized to two study groups E1P and E2 on etoricoxib 30 mg and add-on paracetamol 500 mg 8 hourly and etoricoxib 60 mg once respectively for 3 days. The efficacy was assessed by visual analog scale, pain relief score, and global evaluation score. Patients were assessed at 0, 6, 24, 48, and 72 h. Safety was assessed by adverse drug reactions reported by the patients after 72 h. Cost-effective analysis was done by calculating the cost of treatment and the cost-effective ratio in both groups. Results: Eighty patients completed the study having 40 patients in each group. Mean pain intensity reduction, mean pain relief score, and global evaluation score all showed significantly better results (p
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::d24405f6a620c66eae846b010c1cd505 https://doi.org/10.22159/ajpcr.2022.v15i5.44414 Zobrazit plný text záznamu