The function of oxybuprocaine: a parachute effect that sustains the supersaturated state of anhydrous piroxicam crystals
| Autor: | Yuta Otsuka, Hiroshi Terada, Katsuyuki Inoo, Momoko Fujita, Hitoshi Chatani, Satoru Goto, Yohsuke Shimada |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
chemistry.chemical_classification
Supersaturation Materials science General Chemical Engineering 02 engineering and technology General Chemistry Polymer 021001 nanoscience & nanotechnology Piroxicam 030226 pharmacology & pharmacy 03 medical and health sciences 0302 clinical medicine chemistry Solubilization Chemical physics Anhydrous medicine Oxybuprocaine 0210 nano-technology medicine.drug |
| Zdroj: | RSC Advances. 10:1572-1579 |
| ISSN: | 2046-2069 |
| Popis: | Polymers have been recognized to have the function of sustaining the supersaturated state of drugs. This function has been widely studied because it will improve the absorption of poorly water-soluble drugs. However, clarifying the mechanism of this sustaining pharmaceutical effect (parachute effect) on the supersaturated state as a result of polymers is remains a task. We have found that oxybuprocaine, which is a small molecule, has a parachute effect on the supersaturated state (due to an anhydrate-to-hydrate transformation) of piroxicam-anhydrate in the aqueous phase. We consider that oxybuprocaine controls the environment of the solution and the network of polymers is unnecessary. Therefore, oxybuprocaine not only becomes a clue for elucidating the essential mechanism of the parachute effect of polymers but also enables us to rationally propose a new type of solubilizer. |
| Databáze: | OpenAIRE |
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