The ultra-acute steroid response to traumatic injury: a cohort study
| Autor: | Conor Bentley, Jon Hazeldine, Laura Bravo, Angela E Taylor, Lorna C Gilligan, Fozia Shaheen, Animesh Acharjee, George Gkoutos, Mark A Foster, Wiebke Arlt, Janet M Lord |
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| Rok vydání: | 2023 |
| Předmět: | |
| Zdroj: | European Journal of Endocrinology. 188:290-299 |
| ISSN: | 1479-683X 0804-4643 |
| Popis: | ObjectiveTrauma-induced steroid changes have been studied post-hospital admission, resulting in a lack of understanding of the speed and extent of the immediate endocrine response to injury. The Golden Hour study was designed to capture the ultra-acute response to traumatic injury.DesignWe conducted an observational cohort study including adult male trauma patients MethodsWe recruited 31 adult male trauma patients (mean age 28 [range 19-59] years) with a mean injury severity score (ISS) of 16 (IQR 10-21). The median time to first sample was 35 (range 14-56) min, with follow-up samples collected 4-12 and 48-72 h post-injury. Serum steroids in patients and age- and sex-matched healthy controls (HCs) (n = 34) were analysed by tandem mass spectrometry.ResultsWithin 1 h of injury, we observed an increase in glucocorticoid and adrenal androgen biosynthesis. Cortisol and 11-hydroxyandrostendione increased rapidly, whilst cortisone and 11-ketoandrostenedione decreased, reflective of increased cortisol and 11-oxygenated androgen precursor biosynthesis by 11β-hydroxylase and increased cortisol activation by 11β-hydroxysteroid dehydrogenase type 1. Active classic gonadal androgens testosterone and 5α-dihydrotestosterone decreased, whilst the active 11-oxygenated androgen 11-ketotestosterone maintained pre-injury levels.ConclusionsChanges in steroid biosynthesis and metabolism occur within minutes of traumatic injury. Studies that address whether ultra-early changes in steroid metabolism are associated with patient outcomes are now required. |
| Databáze: | OpenAIRE |
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