Synthesis of important β-functionalized 5-methyl-1H-pyrazol-3-ol derivatives in the presence of γ-alumina catalyst in aqueous medium

Autor:	Md. Rumum Rohman, Hormi Mecadon, Bekington Myrboh, Abu T. Khan
Rok vydání:	2012
Předmět:	chemistry.chemical_classification Aqueous medium Organic Chemistry Hydrazine Biochemistry Aldehyde Catalysis γ alumina chemistry.chemical_compound chemistry Ethyl acetoacetate Drug Discovery Multi-component reaction Organic chemistry
Zdroj:	Tetrahedron Letters. 53:5261-5264
ISSN:	0040-4039
DOI:	10.1016/j.tetlet.2012.07.073
Popis:	The γ-alumina catalyzed synthesis of a new series of β-functionalized 5-methyl-1 H -pyrazol-3-ol derivatives by the multi-component reaction of an aldehyde, ethylcyano acetate, and in situ generated 3-methyl-1 H -pyrazol-5(4 H )-one obtained from hydrazine monohyrade and ethyl acetoacetate in aqueous medium is described. The present reaction forms an important variant of the Yonemitsu-type multi-component reaction. The salient features of this present environmentally benign method are: recyclability of the catalysts, mild reaction condition, excellent yields of product, and the use of aqueous medium in the reaction.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::d23543e3f416019f94a7df03bd2dfdc6 https://doi.org/10.1016/j.tetlet.2012.07.073 Zobrazit plný text záznamu Full Text from ScienceDirect