Cyclic X-Ray Responses in Mammalian Cellsin Vitro1
| Autor: | Warren K. Sinclair |
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| Rok vydání: | 2012 |
| Předmět: | |
| Zdroj: | Radiation Research. 178:AV112-AV124 |
| ISSN: | 1938-5404 0033-7587 |
| Popis: | Various radiation responses in mammalian cells depend on the position of the cell within its generation cycle (that is, its age) at the time of irradiation. Studies have most often been made by irradiating synchronized populations of cells in vitro. Results in different cell lines are not easy to compare, but an attempt has been made here to point out similarities and differences with regard to cell killing and division delay. In general, survival data obtained so far show that, in cells with a short G1, cells are most sensitive in mitosis and in G2, less sensitive in G1, and least sensitive during the latter part of the S period. In cells with a long G1, in addition to the above, there is usually a resistant phase early in G1 followed by a sensitive stage near its end. (The latter may be as sensitive as mitosis.) Exceptions to the above, especially in some L cell sublines, have been noted, and a possible explanation is given. In Chinese hamster cells, maximum survival after irradiation occurs during S, b... |
| Databáze: | OpenAIRE |
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