ChemInform Abstract: Synthesis, Toxicological and Pharmacological Assessment of Morpholinooximes

Autor:	P. D. Avramova, Rossen Buyukliev, N. D. Danchev
Rok vydání:	2010
Předmět:	Pentobarbital Chemistry Central nervous system General Medicine Carbon-13 NMR Pharmacology Locomotor activity Acute toxicity chemistry.chemical_compound medicine.anatomical_structure In vivo Morpholine medicine Proton NMR medicine.drug
Zdroj:	ChemInform. 30
ISSN:	1522-2667 0931-7597
DOI:	10.1002/chin.199941149
Popis:	The synthesis, pharmacology and toxicology of four morpholine derivatives from 1-(2-arylmorpholino)-3-phenyl-3-propanonoxime and the synthesis of two anilides are described. The structures of the synthesized derivatives were proved by IR, 1H NMR and occasionally with 13C NMR. The acute toxicity of the compounds in mice was determined. A comparative pharmacological study of the in vivo effect on the central nervous system was realised by the following screening tests: pentobarbital induced sleeping time, locomotor activity and behaviour despair test for antidepressive activity. The most active compound was 1-(2-phenylmorpholino)-3-phenyl-3-propanonoxime (2b) which showed low toxicity and antidepressive activity at a dose of 1/10 LD50.
Databáze:	OpenAIRE
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