Loss of MeCP2 increases GABA uptake by astrocytes to suppress tonic inhibition of CA1 pyramidal neurons

Autor:	Brenda M Milla
Rok vydání:	2021
Předmět:	Physiology General Neuroscience Tonic inhibition Rett syndrome Biology medicine.disease Phenotype MECP2 Neurodevelopmental disorder medicine.anatomical_structure nervous system medicine Neuroscience Astrocyte
Zdroj:	Journal of Neurophysiology. 126:1310-1313
ISSN:	1522-1598 0022-3077
DOI:	10.1152/jn.00222.2021
Popis:	Rett syndrome (RTT) is a neurodevelopmental disorder characterized a spectrum of phenotypes affecting neuronal and glial populations. Recent work by Dong et al. (Dong Q, Kim J, Nguyen L, Bu Q, Chang Q. J Neurosci 40: 6250–6261, 2020) suggests that augmented GABA uptake by astrocytes diminishes tonic inhibition in the hippocampus and contributes to increased seizure propensity in RTT. Here, I will review evidence supporting this possibility and critically evaluate how increased expression of a GABA transporter might contribute to this mechanism.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::d2220cd8719cef3a47b4bbebcb11c807 https://doi.org/10.1152/jn.00222.2021 Zobrazit plný text záznamu