Design and optimizing a novel ocular plaque brachytherapy with dual-core of 103Pd and 106Ru

Autor:	Mohsen Sharifzadeh, Mahdi Sadeghi, Tayebeh A. Chiniforoush
Rok vydání:	2021
Předmět:	Ocular cancer Dose calculation business.industry medicine.medical_treatment Brachytherapy Plaque brachytherapy Biophysics General Physics and Astronomy General Medicine Radiation therapy medicine Radiology Nuclear Medicine and imaging Primary treatment Nuclear medicine business Dose rate Dual core
Zdroj:	Physica Medica. 91:99-104
ISSN:	1120-1797
DOI:	10.1016/j.ejmp.2021.10.004
Popis:	In recent decades, eye plaques of brachytherapy have been extensively used as primary treatment as well as a complementary treatment for ocular cancer. The purpose of this study is the development of the eye plaque brachytherapy throughout a new design of eye plaque by combining the COMS plaque and the CCB BEBIG plaque loaded by IRA1-103Pd and 106Ru, respectively. A new dual-core plaque with a diameter of 20 mm was designed in the way that the BEBIG plaque with a diameter of 20 mm loaded by 106Ru plate is attached to the COMS plaque with a diameter of 20 mm loaded by 24 of IRA1-103Pd seeds. Dose calculations for the new plaque were performed by using the MCNP5 code. Dose calculations of dual-core plaque including 103Pd seeds (gamma) and 106Ru plate (beta) were separately done for the sake of MCNP constraints in gamma and beta particle transfer simultaneously. The new dual-core plaque delivers a much higher dose rate to the tumor compared with every single plaque, while the dose rate reached to healthy tissues is slightly higher than each plaque separately. Of course, this is acceptable because the treatment time reduces and subsequently the error in radiation therapy reduces.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::d21f02537301ca5eaf9970646e4d23a8 https://doi.org/10.1016/j.ejmp.2021.10.004 Zobrazit plný text záznamu Full Text from ScienceDirect