Synthesis of a phosphoramidite of 2′-deoxy-5,6-dihydro-5-azacytidine. Its potential application in the synthesis of DNA containing dihydro-5-aza-and 5-azacytosine bases

Autor:	Victor E. Marquez, Amanda J. Goddard
Rok vydání:	1988
Předmět:	Phosphoramidite DNA synthesis Oligonucleotide Chemistry Stereochemistry Dimer Organic Chemistry Pyrimidine dimer Oligonucleotide synthesis Ring (chemistry) Biochemistry Dihydro-5-Azacytidine chemistry.chemical_compound Drug Discovery
Zdroj:	Tetrahedron Letters. 29:1767-1770
ISSN:	0040-4039
DOI:	10.1016/s0040-4039(00)82037-7
Popis:	A novel phosphoramidite ( 9 ) has been synthesized and shown to be an efficient coupling reagent for the synthesis of oligonucleotide fragments containing the modified base 5,6-dihydro-5-azacytosine. With a model dihydro-5-azacytosine/thymine dimer ( 12 ), oxidation of the dihydrotriazine ring to the aromatic base was partially successful.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::d21ee567edc50963f9008d487d8af655 https://doi.org/10.1016/s0040-4039(00)82037-7 Zobrazit plný text záznamu